Main pic

Mali Halac

Ph.D. student in Bioengineering @Harvard
I design neural interfaces :)

Curriculum Vitae (CV)

    Education

  1. Harvard University (2023-Present) — Cambridge, MA


  2. Ph.D. Bioengineering

  3. Biohybrid Organs & Neuroprosthetics (Bionics) Lab

  4. Advisor: Dr. Shriya Srinivasan

  5. Drexel University (2019-2023) — Philadelphia, PA


  6. B.S. Electrical Engineering

  7. Concentrations: Wireless Electronics, Digital Signal Processing, Control Theory

  8. Organizations:

  9. • President ('22-'23), IEEE Eta Kappa Nu Honor Society

  10. • Member, Drexel Society of Artificial Intelligence

  11. • Member, Drexel Neuroscience Collaborative

  12. Galatasaray High School (2014-2019) — Istanbul, Turkey


  13. Research Experience

  14. Senior Thesis Research — Sep. 2022 – Present
    @Ecological and Evolutionary Signal Processing & Informatics (EESI) Lab, Drexel University


  15. • Designed a whole brain model to quantify intersubject variation in functional connectivity architecture of attention and working memory.
    • Analyzed single nucleotide polymorphisms (SNP), structural variants (SV), and gene expression patterns to determine the genetic origins of intersubject variation in these cognitive functions.


  16. Research Assistant, Machine Learning & Neuromorphic Computing — Sep. 2021 – Mar. 2022
    @Distributed Intelligent Scalable Computing (DISCO) Lab, Drexel University


  17. • Designed a generative model for the enhanced reconstruction of perceived images from human brain activity.
    • Worked on the FPGA acceleration of this generative model.


  18. Computational Biology Research Co-op — Mar. 2021 – Sep. 2022
    @Ecological and Evolutionary Signal Processing & Informatics (EESI) Lab, Drexel University


  19. • Designed a semi-supervised continual learning algorithm that analyzes amino acid sequences to infer protein functions (>98% accuracy) while reducing the computational cost to update big biological databases (1.65 times less memory usage)
    • Taught “Intro to Bash/Unix” at 2021 Biological Data Science Summer Workshop organized by our lab.


  20. VIP Research, Machine Learning & Neuromorphic Computing — Sep. 2020 – Mar. 2021
    @Distributed Intelligent Scalable Computing (DISCO) Lab, Drexel University


  21. • Worked on using machine learning models (VGG19, GAN, DNN) to analyze fMRI scans of human visual cortex with the purpose of reconstructing visual experiences.


  22. Research Assistant, Neuroengineering — Sep. 2020 – Mar. 2021
    @Neuroengineering & Neuroergonomics Lab, Drexel University


  23. • Worked on the development of a low-cost brain-computer interface (BCI) system for people with Amyotrophic Lateral Sclerosis (ALS).
    • Designed the P300 brain wave-based control system that turns brain signals into computer commands for home environment control—turning on/off lights, TV, and A/C.
    • Designed the user interface for the BCI.


    Work Experience

  24. Consultant, Computational Biology — Oct. 2022 – Present
    @Flagship Labs 95, Inc.


  25. • Built a novel computational discovery and development platform for noncanonical viral vector-based programmable medicines.


  26. Consultant, Computational Biology — Oct. 2022 – Present
    @Flagship Labs 70, Inc.


  27. • Designed computational models for RNA structure analysis, metagenomics, and viral vector based cargo delivery for plant therapeutics.


  28. Computational Biologist (Co-op) — Mar. 2022 – Sept. 2022
    @Flagship Labs 70, Inc.


  29. • Project lead for computational virus discovery.
    • Designed metagenomics pipelines for Illumina MiSeq, Nanopore MinION, PacBio, BGISEQ, and Sanger sequencing data.
    • Automated quality control for NGS data.
    • Designed a taxonomic classifier sensitive at the genus level for RNA viruses.
    • Designed a probabilistic model for viral host prediction.
    • Automated peak alignment for nucleic acid capillary electrophoresis analysis via dynamic time warping. A critical step for high-throughput RNA structure analysis.
    • Automated data transfer from Illumina MiSeq to AWS S3.
    • Performed gel electrophoresis and microinjections.


  30. Teaching Assistant, "ENGR 131: Introductory Programming for Engineers" — Sept. 2021 – Mar. 2022
    @Drexel University


  31. • Designed programming exercises and projects for Python with Dr. Andrew Cohen for the winter term of the 2021-2022 academic year..
    • Supervised students with their programming assignments.


    Skills

  32. Programming


  33. Shell scripting, Matlab, Python, R, Julia, C++, Nextflow, VHDL, HTML, CSS


  34. Machine Learning


  35. CNN, GAN, LSTM, PCA, Diffusion Models, Tensorflow


  36. Software


  37. AWS, Docker, Slurm, NI Multisim, PathWave ADS, Linux, Code Ocean, MS Office, Google Colab


  38. Neuroengineering


  39. EEG, fNIRS, MRI, PET, SPM 12, FSL, OpenVibe


  40. Sequencing Analysis


  41. Illumina MiSeq, Nanopore MinION, PacBio, BGISEQ, Sanger, RACE


  42. Engineering Expertise


  43. RF Circuit Design, Digital Logic Design, Digital Signal Processing, Oscilloscope, High Performance Computing


  44. Languages


  45. English (fluent), French (fluent), Turkish (Fluent), German (Intermediate)


    Peer-Reviewed Conference Publications

  46. M. Halac, M. Isik, H. Ayaz and A. Das, "Multiscale Voxel Based Decoding For Enhanced Natural Image Reconstruction From Brain Activity," 2022 International Joint Conference on Neural Networks (IJCNN), 2022, pp. 1-7, doi: 10.1109/IJCNN55064.2022.9892430.

  47. M. Halac, B. Sokhansanj, W. Trimble, T. Coard, N. Sabin, E. Ozdogan, R. Polikar, G. Rosen, "Incremental & Semi-Supervised Learning for Functional Analysis of Protein Sequences," 2021 IEEE Symposium Series on Computational Intelligence (SSCI), 2021, pp. 01-08, doi: 10.1109/SSCI50451.2021.9659958.

  48. E. Ozdogan, N. Sabin, T. Gracie, S. Portley, M. Halac, T. Coard, W. Trimble, B. Sokhansanj, G. Rosen, R. Polikar, "Incremental and Semi-Supervised Learning of 16S-rRNA Genes For Taxonomic Classification," 2021 IEEE Symposium Series on Computational Intelligence (SSCI), 2021, pp. 1-7, doi: 10.1109/SSCI50451.2021.9660093.

  49. M. Sahal, E. Dryden, M. Halac, S. Feldmen, T. Heiman-Patterson, H. Ayaz, "Augmented Reality Integrated Brain Computer Interface for Smart Home Control," Advances in Neuroergonomics and Cognitive Engineering (pp. 89--97), 2021, Springer International Publishing.
  50. Peer-Reviewed Abstracts

  51. M. De Lorenzo, M. Halac, S. Sivakumar, H. Ayaz, "Deep Neural Network Modeling Using CNN and BiLSTM for Online Passive EEG Brain-Computer Interface to Classify Mental Workload," 2021 Neuroergonomics Conference, 2021.
  52. Preprints

  53. E. Moyer, J. Winchell, I. Isozaki, Y. Alparslan, M. Halac, E. Kim, "Functional Protein Structure Annotation Using a Deep Convolutional Generative Adversarial Network," 2021, arXiv: 2104.08969.
  54. Patents

  55. Polynucleotides for Modifying Organisms, Provisional filed 11 Oct 2022, International (PCT) and AR, UY, PY applications filed 31 Oct 2022
  56. Polynucleotides for Modifying Organisms, Provisional filed 11 Oct 2022
  57. Awards & Honors

  58. Outstanding Undergraduate Student Award — Jan. 2023
  59. Undergraduate Research Mini Grants — Nov. 2022
  60. Dean's List — 2019-2023
  61. Nomination, BCI Award — 2021
  62. Dean's Scholarship — 2019
  63. Affiliations

  64. RNA Society, Member — 2024 - Present
  65. Biomedical Engineering Society (BMES), Member — 2024 - Present
  66. American Academy of Pain Medicine (AAPM), Member — 2024 - Present
  67. American Society of Pain & Neuroscience (ASPN), Member — 2024 - Present
  68. IEEE Computational Intelligence Society (CIS), Member — 2022 - Present
  69. IEEE, Member — 2021 - Present